After a shoot-out kills five FBI agents in Kansas City the Bureau target John Dillinger as one of the men to hunt down. Waiting for him to break Federal law they sort out several other mobsters, while Dillinger's bank robbing exploits make him something of a folk hero. Escaping from jail he finds Pretty Boy Floyd and Baby Face Nelson have joined the gang and pretty soon he is Public Enemy Number One. Now the G-men really are after him.

Lou-Jean, a blonde woman, tells her husband, who is imprisoned, to escape. They plan to kidnap their own child...

Jack Beauregard, once the greatest gunslinger of the Old West, only wants to move to Europe and retire in peace. But a young gunfighter, known only as "Nobody", idolizes him and wants to see him go out in a blaze of glory. He arranges for Jack to face the 150-man gang known as The Wild Bunch and earn his place in history.